Endocrine Abstracts

Background: The serum concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Pregnancy is associated with increases in plasma lipid profiles. Identifying the genetic determinants could provide novel insights into mechanisms of dyslipidemia and reveal avenues for developing new therapies. The objective of this study was to investigate the impact of six single nucleotide polymorphisms (SNPs) on serum lipid levels during pregnancy.<p ...

Objective: To determine if autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was worthwhile to do in type 1 diabetes adolescents with diabetic ketoacidosis at diagnosis.Research Design and Methods: We enrolled 28 type 1 diabetes patients aged 14–30 years in a prospective AHSCT phase II clinical trial. Hematopoietic stem cells were harvested from the peripheral blood following a pretreatment consisting of a combination of cy...

Cancer cells have shown an overexpressed fructose transporter GLUT5 and preferential utilization of fructose as compared to glucose, implicating that a fructose-based analogue would be a useful target for diagnosis and treatment of cancer. We have successfully synthesized the fructose conjugated-gefitinib compounds {N-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxy-quinazolin-6-yl]-4- [N-methyl-N-(1-deoxy-1-fructosyl)]aminobutanamide}, and examined its antitumor effic...